Findings from the 2022 Ghana Demographic and Health Survey (DHS) indicate that malaria prevalence in children aged 6 to 59 months is 8.6 percent according to microscopy results. The malaria prevalence in rural areas (12.8%) is about three times that of urban (4.3%). Greater Accra (2.0%) has the lowest prevalence followed by Western North (4.4%) and Volta (6.4%). The regions with the highest prevalence of malaria according to microscopy results are Oti (15.0%), Upper West (13.4%), and the Upper East (12.2%) regions. In all, half of the 16 regions record malaria prevalence above 10 percent.